Regulation of β-adrenergic receptor function
نویسندگان
چکیده
منابع مشابه
β-Adrenergic receptor signaling in cardiac function and heart failure
INTRODUCTION Congestive heart failure (CHF) is a major public health problem. Nearly 5 million Americans are afflicted with CHF and about 550,000 new cases are diagnosed each year (1). CHF is a pathophysiological condition in which the heart is unable to pump enough blood to meet the metabolic needs of the body. It is the endpoint for several cardiovascular diseases including coronary artery di...
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Normal hearts have increased contractility in response to catecholamines. Because several lipids activate PKCs, we hypothesized that excess cellular lipids would inhibit cardiomyocyte responsiveness to adrenergic stimuli. Cardiomyocytes treated with saturated free fatty acids, ceramide, and diacylglycerol had reduced cellular cAMP response to isoproterenol. This was associated with increased PK...
متن کاملMolecular mechanisms of beta2-adrenergic receptor function and regulation.
It is now clear that the beta2-adrenergic receptor continuously oscillates between various conformations in the basal state, and that agonists act to stabilize one or more conformations. It is conceivable that synthetic agonists might be engineered to preferentially confine the receptor to certain conformations deemed clinically important while having a less stabilizing effect on unwanted confo...
متن کاملRegulation of β-Adrenergic Receptor Signaling by S-Nitrosylation of G-Protein-Coupled Receptor Kinase 2
beta-adrenergic receptors (beta-ARs), prototypic G-protein-coupled receptors (GPCRs), play a critical role in regulating numerous physiological processes. The GPCR kinases (GRKs) curtail G-protein signaling and target receptors for internalization. Nitric oxide (NO) and/or S-nitrosothiols (SNOs) can prevent the loss of beta-AR signaling in vivo, but the molecular details are unknown. Here we sh...
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Alterations in platelet o2-adrenoceptor and mononuclear leucocyte ß2-adreno-ceptor characteristics in primary hypertension have been studied quite exten-sively The results of these studies are not consistent, which may be due to therelatively small number of subjects in most of the studies. In the present study,the o2-adrenoceptor characteristics were compared between 65 hyperte...
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ژورنال
عنوان ژورنال: Cell Cycle
سال: 2011
ISSN: 1538-4101,1551-4005
DOI: 10.4161/cc.10.21.18042